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Search Results for " muscarinic acetylcholine receptor m5 "

Targets Recommended: AChR

抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T8007	VU 0238429 SCR-1481B1,VU0238429	AChR	Neuroscience
	VU 0238429 (SCR-1481B1) 是毒蕈碱乙酰胆碱受体亚型 5 的正变构调节剂，EC50为1.16 μM。
T8219	VU0238441	AChR	Neuroscience
	VU0238441是一种泛毒蕈碱型乙酰胆碱受体阳性变构调节剂，对 M1、M2、M3、M5 和 M4 的EC50分别为 3.2、2.8、2.2、2.1 和大于 10 μM。
T12679	(Rac)-VU 6008667	Others; AChR	Neuroscience; Others
	(Rac)-VU 6008667 是一种选择性的毒蕈碱乙酰胆碱受体亚型 5（M5 NAM）负异位调节剂，IC50 为 1.8 μM，pIC50 为 5.75，具有较高的中枢神经系统渗透性。
T1475	Fesoterodine fumarate Toviaz,SPM 907,富马酸非索罗定	AChR	Neuroscience
	Fesoterodine fumarate (Toviaz) 是可口服的，非亚型选择性的竞争性毒蕈碱受体拮抗剂，用于膀胱过度活动症，对 M1、M2、M3、M4 和 M5 受体的pKi 值分别为 8.0、7.7、7.4、7.3 和 7.5。
T37728	Methoctramine (hydrate)
	Methoctramine is a selective antagonist of M2 muscarinic acetylcholine receptors (IC50 = 6.1 nM in CHO-K1 cell membranes).[1] It is selective for M2 over M1, M3, M4, and M5 receptors (IC50s = 92, 770, 260, and 217 nM, respectively). In vitro, methoctramine inhibits acetylcholine-induced reductions in isolated guinea pig tracheal tube contractions when used at a concentration of 1 μM.[2] In vivo, methoctramine inhibits bradycardia and bronchoconstriction induced by acetylcholinein guinea pigs wit...
T23763	Atropine Oxide NSC 72861,NSC72861,NSC-72861
	Atropine Oxide is a derivative of Atropine. Atropine is a competitive antagonist of the muscarinic acetylcholine receptor types M1, M2, M3, M4, and M5. Atropine is a medication to treat certain types of nerve agents and pesticide poisonings as well as som
T69232	Atropine Oxide Hydrochloride
	Atropine Oxide is a derivative of Atropine. Atropine is a medication to treat certain types of nerve agent and pesticide poisonings as well as some types of slow heart rate and to decrease saliva production during surgery. Atropine is a competitive antagonist of the muscarinic acetylcholine receptor types M1, M2, M3, M4 and M5. It is classified as an anticholinergic drug (parasympatholytic).

化合物

VU 0238429

Cat.No: T8007

Synonym: SCR-1481B1,VU0238429

Target: Others, AChR

Fesoterodine fumarate

Cat.No: T1475

Synonym: Toviaz,SPM 907,富马酸非索罗定

Target: AChR

Methoctramine (hydrate)

Synonym: NSC 72861,NSC72861,NSC-72861

Target:

Atropine Oxide Hydrochloride

Cat.No: T69232

Synonym:

Target:

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01717	CHRM5 Protein, Human, Recombinant (His) CHRM5,Muscarinic acetylcholine	Human	E. coli
	The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. CHRM5 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.5 kDa and the accession number is P08912.